Young-Chae Chang Selected Research

ascochlorin

10/2020	4-O-methylascochlorin activates autophagy by activating AMPK and suppressing c-Myc in glioblastoma.
12/2019	4-O-methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition.
7/2019	Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages.
1/2019	4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate.
1/2018	Ascochlorin Suppresses MMP-2-Mediated Migration and Invasion by Targeting FAK and JAK-STAT Signaling Cascades.
1/2018	Suppression of c-Myc enhances p21WAF1/CIP1 -mediated G1 cell cycle arrest through the modulation of ERK phosphorylation by ascochlorin.
12/2016	Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma.
4/2016	Anti-Inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-κB, ERK1/2, and p38 Signaling Pathway.
5/2012	4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells.
7/2010	Ascochlorin, an isoprenoid antibiotic, induces G1 arrest via downregulation of c-Myc in a p53-independent manner.

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Young-Chae Chang Research Topics

Disease

43	Neoplasms (Cancer) 01/2021 - 10/2003
14	Inflammation (Inflammations) 01/2021 - 02/2004
14	Neoplasm Metastasis (Metastasis) 01/2019 - 11/2004
12	Fibrosis (Cirrhosis) 12/2014 - 05/2004
9	Breast Neoplasms (Breast Cancer) 01/2017 - 04/2005
8	Atherosclerosis 01/2021 - 12/2006
8	Lung Neoplasms (Lung Cancer) 08/2020 - 08/2012
7	Osteosarcoma (Osteogenic Sarcoma) 12/2019 - 06/2004
6	Leukemia 10/2020 - 05/2008
6	Hepatocellular Carcinoma (Hepatoma) 05/2019 - 02/2004
6	Carcinoma (Carcinomatosis) 12/2013 - 11/2007
6	Insulin Resistance 05/2013 - 02/2008
5	Hypoxia (Hypoxemia) 12/2019 - 03/2011
5	Arthritis (Polyarthritis) 04/2015 - 07/2003
4	Pain (Aches) 05/2013 - 03/2007
4	Rheumatoid Arthritis 05/2013 - 12/2006
3	Hypertension (High Blood Pressure) 01/2021 - 10/2006
3	Urinary Bladder Neoplasms (Bladder Cancer) 08/2019 - 01/2013
3	Glioma (Gliomas) 12/2017 - 05/2009
3	Anaphylaxis (Anaphylactic Shock) 01/2017 - 12/2011
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2017 - 08/2008
3	Ureteral Obstruction 10/2013 - 08/2006
3	Type 2 Diabetes Mellitus (MODY) 05/2013 - 02/2008
3	Bone Resorption 08/2004 - 08/2003
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 09/2018
2	Arteriosclerosis 01/2021 - 01/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 12/2013
2	Rheumatic Diseases (Rheumatism) 04/2015 - 01/2013
2	Skin Diseases (Skin Disease) 04/2015 - 07/2014
2	Liver Diseases (Liver Disease) 12/2014 - 05/2004
2	Liver Cirrhosis (Hepatic Cirrhosis) 08/2014 - 05/2006
2	Colonic Neoplasms (Colon Cancer) 01/2014 - 06/2009
2	Experimental Arthritis 12/2008 - 09/2006
2	Neuroblastoma 04/2005 - 12/2003
2	Carcinogenesis 11/2004 - 02/2004

Drug/Important Bio-Agent (IBA)

15	ascochlorinIBA 10/2020 - 04/2005
15	Proteins (Proteins, Gene)FDA Link 10/2020 - 05/2006
12	Matrix Metalloproteinases (MMPs)IBA 01/2021 - 08/2003
12	Bee Venoms (Bee Venom)IBA 01/2019 - 12/2006
11	Anti-Bacterial Agents (Antibiotics)IBA 10/2020 - 11/2007
10	CytokinesIBA 01/2021 - 08/2003
9	Melitten (Melittin)IBA 01/2021 - 02/2010
8	ascofuranoneIBA 10/2020 - 09/2008
7	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2019 - 07/2005
5	Epidermal Growth Factor (EGF)IBA 08/2020 - 01/2013
5	Transcription Factors (Transcription Factor)IBA 12/2019 - 11/2007
5	Antineoplastic Agents (Antineoplastics)IBA 07/2019 - 03/2011
5	Terpenes (Terpenoids)IBA 01/2018 - 09/2008
5	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 09/2017 - 04/2005
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2015 - 08/2003
5	NF-kappa B (NF-kB)IBA 04/2015 - 11/2004
4	4-O-methylascochlorinIBA 10/2020 - 03/2011
4	Pharmaceutical PreparationsIBA 03/2019 - 11/2007
4	4-O-carboxymethylascochlorinIBA 01/2019 - 12/2006
4	AMP-Activated Protein KinasesIBA 01/2017 - 06/2010
4	Peptides (Polypeptides)IBA 04/2015 - 12/2003
4	Collagen Type II (Type II Collagen)IBA 04/2015 - 07/2003
4	OligodeoxyribonucleotidesIBA 08/2014 - 10/2003
4	Glucose (Dextrose)FDA LinkGeneric 01/2013 - 04/2005
3	Anti-Allergic Agents (Antiallergic Agents)IBA 01/2021 - 12/2011
3	Biological ProductsIBA 01/2021 - 06/2014
3	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2019 - 08/2012
3	LipopolysaccharidesIBA 10/2018 - 01/2010
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2017 - 01/2013
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2017 - 01/2010
3	ApaminIBA 04/2015 - 02/2010
3	caffeic acid phenethyl esterIBA 08/2014 - 11/2004
3	G(M3) GangliosideIBA 08/2014 - 01/2013
3	Triglycerides (Triacylglycerol)IBA 06/2012 - 10/2006
3	ProteomeIBA 10/2009 - 10/2006
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 03/2007
2	AntioxidantsIBA 01/2021 - 03/2007
2	Actins (F Actin)IBA 10/2020 - 01/2019
2	CaspasesIBA 12/2018 - 01/2017
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2018 - 01/2018
2	phenethyl isothiocyanate (PEITC)IBA 09/2017 - 12/2015
2	IsothiocyanatesIBA 09/2017 - 12/2015
2	HexanesIBA 01/2017 - 07/2013
2	EnzymesIBA 12/2015 - 11/2004
2	Therapeutic UsesIBA 06/2015 - 11/2004
2	Plasminogen Activator Inhibitor 1IBA 01/2014 - 10/2009
2	Collagen Type I (Type I Collagen)IBA 01/2014 - 08/2006
2	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 12/2013 - 01/2013
2	FlavonoidsIBA 06/2013 - 03/2007
2	Free RadicalsIBA 01/2013 - 12/2006
2	Alanine Transaminase (SGPT)IBA 01/2010 - 05/2004
2	Aspartate Aminotransferases (Aspartate Transaminase)IBA 01/2010 - 05/2004
2	Transforming Growth Factors (Transforming Growth Factor)IBA 05/2009 - 05/2006
2	Interleukin-1beta (Interleukin 1 beta)IBA 05/2009 - 08/2003
2	Estrogen ReceptorsIBA 11/2007 - 04/2005
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 03/2007 - 02/2004
2	Interleukin-1 (Interleukin 1)IBA 09/2006 - 08/2003
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 08/2006 - 05/2006
2	Glutamic Acid (Glutamate)FDA Link 04/2005 - 12/2003
2	Cathepsin KIBA 08/2004 - 11/2003
1	fisetinIBA 01/2022
1	Cytochromes c (Cytochrome c)IBA 01/2022

Therapy/Procedure

9	Therapeutics 01/2020 - 04/2005
2	Traditional Medicine (Folk Remedies) 01/2017 - 04/2015
2	Oral Administration 11/2004 - 02/2004